Code:
  Private Sub ccpSelCheck()
    'Enables and Disables Menu and ToolBar (Cut,Copy & Paste controls) based on Clipboard and Selected Text
    mnuEditCut.Enabled = False
    mnuEditCopy.Enabled = False
    mnuEditPaste.Enabled = Not (My.Computer.Clipboard.GetText = "")
    tbToolBar.Items.Item("_Cut").Enabled = False
    tbToolBar.Items.Item("_Copy").Enabled = False
    tbToolBar.Items.Item("_Paste").Enabled = Not (My.Computer.Clipboard.GetText = "")

    'Cast ActiveControl as generic text control
    If CType(Me.ActiveControl, TextBoxBase).SelectedText <> "" Then
      mnuEditCut.Enabled = True
      mnuEditCopy.Enabled = True
      tbToolBar.Items.Item("_Cut").Enabled = True
      tbToolBar.Items.Item("_Copy").Enabled = True
    End If
  End Sub

  Private Sub frmMain_KeyUp(ByVal eventSender As System.Object, ByVal eventArgs As System.Windows.Forms.KeyEventArgs) Handles MyBase.KeyUp
    'NOTE: KeyPreview for the Form must be set to True
    ccpSelCheck()
  End Sub

  Private Sub TextOrCombo_MouseUp(ByVal eventSender As System.Object, ByVal eventArgs As System.Windows.Forms.MouseEventArgs) Handles tbFiled1.MouseUp, tbField2.MouseUp, cbOprion1.MouseUp
    'MouseUp event may have selected text
    ccpSelCheck()
  End Sub


 Private Sub TextOrCombo_KeyPress(ByVal eventSender As System.Object, ByVal eventArgs As System.Windows.Forms.KeyPressEventArgs) Handles tbFiled1.Enter, tbField2.Enter, cbOprion1.Enter
    'KeyPress event may have selected text
    ccpSelCheck()
  End Sub

  'For Toolbar Events Use the PerformClick Method to trigger menu Cut, Copy, and Paste click events
  'NOTE: These Controls are only enabled when there is something to act upon, (clipboard, or selected text)
  Public Sub mnuEditPaste_Click(ByVal eventSender As System.Object, ByVal eventArgs As System.EventArgs) Handles mnuEditPaste.Click
    Dim txc As TextBoxBase = CType(Me.ActiveControl, TextBoxBase)
    txc.SelectedText = My.Computer.Clipboard.GetText()
    mnuEditPaste.Enabled = Not (My.Computer.Clipboard.GetText = "")
  End Sub

  Public Sub mnuEditCopy_Click(ByVal eventSender As System.Object, ByVal eventArgs As System.EventArgs) Handles mnuEditCopy.Click
    Dim txc As TextBoxBase = CType(Me.ActiveControl, TextBoxBase)
    My.Computer.Clipboard.SetText(txc.SelectedText)
    mnuEditPaste.Enabled = Not (My.Computer.Clipboard.GetText = "")
  End Sub

  Public Sub mnuEditCut_Click(ByVal eventSender As System.Object, ByVal eventArgs As System.EventArgs) Handles mnuEditCut.Click
    Dim txc As TextBoxBase = CType(Me.ActiveControl, TextBoxBase)
    My.Computer.Clipboard.SetText(txc.SelectedText)
    mnuEditPaste.Enabled = Not (My.Computer.Clipboard.GetText = "")
    'Cut selected text.
    txc.SelectedText = ""
  End Sub